Dubai PR Network, Online Press Release from Dubai and Middle East
 
Education, Universities & Training(Education & Training)
Filter PR by
  
NYU Abu Dhabi researchers develop hybrid molecules that could serve as a new category of anti-cancer agents
 
  • New findings are published in the journal Chemical Science
  • “There is significant promise for developing new cancer therapies that can complement the existing chemotherapy options that are currently used to treat nearly half of all cancer patients undergoing chemotherapy,” explains Ali Trabolsi

Abu Dhabi, May 23, 2019:  Researchers from NYU Abu Dhabi’s (NYUAD) chemistry program and colleagues from the University’s biology program have developed and studied the biological activity of five new, metal-organic hybrid knotted molecules, termed metal-organic trefoil knots (M-TKs). These molecules can effectively deliver metals to cancer cells, demonstrating the potential to act as a new category of anti-cancer agents. 

In a study published in the journal Chemical Science, NYUAD Research Scientists Farah Benyettou and Thirumurugan Prakasam from the Trabolsi Research Group, led by NYUAD Associate Professor of Chemistry Ali Trabolsi, report that these nanoscale, water-soluble M-TKs showed high potency in vitro against six cancer cell lines and in vivo in zebrafish embryos. Zebrafish-related studies were performed by NYUAD Postdoctoral Associate Anjana Ramdas Nair from the Sadler Lab.

The M-TKs, generated by metal-templated self-assembly of a simple pair of chelating ligands, were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin, a common chemotherapy medication, in both human cancer cells––including those that were cisplatin-resistant––and in zebrafish embryos. In cultured cells, M-TKs introduce reactive oxygen species (ROS) that damage the mitochondria of cancer cells, but not the nuclear DNA or the plasma membrane. 

“The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development,” said Trabolsi. “There is significant promise for developing new cancer therapies that can complement the existing chemotherapy options that are currently used to treat nearly half of all cancer patients undergoing chemotherapy.”

Benyettou said, “The M-TKs synthesized by NYUAD Research Scientist Thirumurugan Prakasam from the Trabolsi Research Group were found, in many cases, to have greater potency than has been previously reported in cisplatin and other metal complexes, explains NYUAD Research.” 

“The main delivery routes were macropinocytosis and both caveolin- and clathrin-mediated endocytosis, which are all more active in cancer cells than in normal cells. Cisplatin and other small molecules penetrate cells by diffusion, which is less cancer-selective in vitro. The researchers hypothesize that the molecules they have developed are less toxic to healthy cells because they are internalized less,” added Benyettou.

In the next stage of developing M-TKs,  research efforts will focus on the mechanism of action of the M-TKs to determine whether their ROS-mediated toxicity involves specific intracellular targets.

These findings confirm the viability of studying the effects of these compounds in whole vertebrates, as the M-TKs were well tolerated by zebrafish and appeared to selectively attack dividing cells. 

Other NYUAD collaborators include fourth year graduate PhD student Tina Skorjanc, who contributed to the paper’s biological-related aspects. 

The research was carried out using the Core Technology Platform resources at NYUAD, which are shared facilities that support research activities across disciplines. 


Posted by : Dubai PR Network Editorial Team
Viewed 8357 times
PR Category : Education & Training
Posted on : Thursday, May 23, 2019  1:11:00 PM UAE local time (GMT+4)
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of DubaiPRNetwork.com.
Previous Story : Repton, Abu Dhabi's iftar marks International Day of Familie...
Next Story : Dubai Cares successfully wraps up its Ramadan volunteering i...
Email this article Print this article

Share this article with your friends and followers
NewsVine
Back to Section Home

Related Stories



 
 
Most Viewed Press Release posted in the last 7 days
Holiday Hair-Styling Essentials from VIERRO [12249-Views]
'Tis the Season to Be Glamorous - Beauty Essentials from GlamBeaute.com! [12121-Views]
Luxe Beauty Gifts for your Loved Ones this Festive Season [12115-Views]
Chloé's Iconic “Carlina” Sunglasses In a Precious New Interpretation [11657-Views]
Your Holiday Gift Guide for Her [11620-Views]
Homegrown Jewellery Brand Sumaya Bakkar Collections Curated Festive Gift List [11303-Views]
New year, New You with Lunette [10150-Views]
Uncovering the Beauty of Mechanics' [10132-Views]
Weather-proof your hair with HASK [9620-Views]
Free gold coins at Malabar Gold & Diamonds Festival. [9211-Views]
Eberhard & Co. and the new “Quadrifoglio Verde” chronograph, dedicated to the prestigious... [8772-Views]
The Real Secret to 10 Years Younger: Argan Face Oil [8418-Views]
OMEGA Celebrates The New James Bond Watch in New York [8345-Views]
Retrograde Fusion' [7460-Views]
Mouawad and the Miss Universe Organization Unveil the Miss Universe Power of Unity Crown, ... [6179-Views]
Berkan Steakhouse Launches in Dubai [5630-Views]
Cole Haan Makes Its Debut at Sole Dxb 2019 Showcasing Footwear Collaborations [4490-Views]
Dubai Festival City Mall Visitors In for A Jolly Festive Season Like No Other in Dubai [4484-Views]
NYU Abu Dhabi Class of 2017 graduate Alioune Fall named as 2021 Schwarzman Scholar [4252-Views]
Emotional and highly dynamic: the design of the MINI John Cooper Works GP. [4240-Views]
Dubai Cares' Volunteers bring hope to children in remote village in Senegal [4227-Views]
Best Menswear Items [3989-Views]
Customs World inks MoU with Indonesia to roll out World Logistics Passport [3989-Views]
Statement Cardigans [3904-Views]
DP World joins forces with Dubai Cares in giving a new facelift to Umm Al Qura School in U... [3849-Views]
 
RSS Facebook Twitter LinkedDin
 
Top Sections
 
Top Stories