Dubai PR Network, Online Press Release from Dubai and Middle East
 
Education, Universities & Training(Education & Training)
Filter PR by
  
A microchip developed by NYU Abu Dhabi researchers provides a new method for understanding how T cells react to infections and treatments
 
Fast facts:
  •  NYU Abu Dhabi researchers have developed a microchip that can isolate T cells, in a systematic and precise manner
  •  T cells are a type of white blood cell that is important to the immune system and is at the core of immunity, the system that tailors the body's immune response to specific pathogens (bacteria, virus, or other microorganism that can cause disease)
  •  The microchip will help researchers to identify, and track in time, the amount of cytokines released from each cell
  •  Cytokines are small proteins released by cells that have a specific effect on the interactions between cells, on communications between cells or on the behavior of cells
  •  The cytokines include interleukins, lymphokines, and cell signal molecules, such as tumor necrosis factor and interferons, which trigger inflammation and respond to infections
  • The study was published in Advanced Therapeutics
 
Abu Dhabi, October 26, 2019:   A team of Engineering researchers from NYU Abu Dhabi (NYUAD) have developed a new microchip that efficiently isolates immune T cells, which would enable researchers to precisely identify the type and amount of released cytokines from each individual cell for immuno-characterization of single T cells. Accurate and real-time measurement of T cells’ responses to various bacteria and viruses is critical to understanding the immune status of patients and evaluating how treatment is efficient as well as the efficacy of new candidate drugs.
 
In the study, “Airplug‐Mediated Isolation and Centralization of Single T Cells in Rectangular Microwells for Biosensing,” published in the journal Advanced Therapeutics, Assistant Professor of Mechanical and Biomedical Engineering Mohammad Qasaimeh and colleagues explain how they developed a microchip that isolates immune T cells from blood samples, in a massive array of rectangular microwells, with a systematic high efficiency of centralized single cell per microwell.
 
They achieved this by engineering in situ generated air bubbles and microfabricated matrix of microwells coated with specific antibodies. The developed system provided precise cytokine detection at the individual cell level. The new chip improved the real-time analysis of the cytokine profiles of single T cells, and could be applied to other immune cells such as B and natural killer cells. T cells’ functional signatures identify the “immune phenotype” of patients, which is an important step toward developing personalized medicine approaches.
 
“The human body’s defense system is highly complex, and the ability to most effectively treat patients has been limited by a lack of understanding about how specific cytokines combat viruses and bacteria,” said corresponding author Qasaimeh. “Immune cells are incredibly heterogeneous because they are disease and patient-specific.”
 
The first author of the study, Research Assistant with NYUAD’s Engineering Division Pavithra Sukumar, commented: “Our findings enable, for the first time, precise unbiased evaluation of the immune response of T cells, isolated within rectangular microwells, for quantitative, real-time analysis of the released cytokines.”
 
Second author in the study, Research Scientist with NYUAD’s Engineering Divisions Muhammedin Deliorman, mentioned: “This isolation of immune cells can help elucidate precisely the immune response of cells at single cell level, especially for phenotyping and biotherapeutics studies.”


Posted by : Dubai PR Network Editorial Team
Viewed 3690 times
PR Category : Education & Training
Posted on : Saturday, October 26, 2019  10:54:00 AM UAE local time (GMT+4)
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of DubaiPRNetwork.com.
Previous Story : GEMS Education launches five specialist Centres of Excellenc...
Next Story : Emirati youth employment program sets new milestone
Email this article Print this article

Share this article with your friends and followers
NewsVine
Back to Section Home

Related Stories



 
 
Most Viewed Press Release posted in the last 7 days
Look after your body & enjoy nourished skin from Local, Homegrown Company, The Simplicity ... [7680-Views]
China's Latest Moves in Ip Protection Leads to Unprecedented Legal Judgement for Swedish S... [5344-Views]
Time for tennis - Ugo Humbert joins Rado YoungStars [5252-Views]
Karama gets crowned. Once more. [4813-Views]
Stack It Up With Shack Stack Now in the UAE! Shake Shack is All About Upping the Burger Ga... [4551-Views]
Steve Madden Celebrates Brand's 30th Anniversary In Dubai [4490-Views]
American Eagle Launches It's Holiday'19 Collection [4465-Views]
Al Tayer Motors launches the new Maserati Quattroporte SQ4 Zegna PELLETESSUTA™ at the Duba... [4380-Views]
The "Karl Legend" Collection [4172-Views]
PCFC discusses wider horizons for trade and logistic services with Dubai business groups [4111-Views]
Monochromatic Denim [4081-Views]
Parmigiani Fleurier Tonda Chronor Slate [3965-Views]
The perfect Watch from Beach to Tux [3886-Views]
Al Tayer Motors Opens Magnificent New Maserati Showroom In Dubai [3806-Views]
Emirati Musicians, International Composers & the Royal Philharmonic Orchestra in Harmony F... [3666-Views]
National Geographic Abu Dhabi Provides an Unprecedented Look into Makkah's Sprawling Hospi... [3660-Views]
Massive Diabetes Awareness and Management Drive in Ras Al Khaimah to screen thousands [3648-Views]
Hamdan bin Mohammed leads first Dubai Run on Sheikh Zayed Road featuring 70,000 participan... [3642-Views]
Redefine Your Winter Wardrobe with REDTAG! [3630-Views]
Accor's role as Makkah's leading pilgrim hospitality services provider showcased in Nation... [3593-Views]
Humans in Space Symposium discusses what it takes to be an astronaut [3568-Views]
‘Carpet of Tolerance' created by Hands and Senses revealed at Downtown Design, Dubai [3526-Views]
Rivoli Group Announces Winners of the Third Qualifier Tournament for Omega Nations Golf To... [3465-Views]
P&O Marinas and Fabulous Yachts Announce the 3rd Edition of the International Superyacht ... [3434-Views]
Dubai Design Week and the first Rado Star Prize UAE [3428-Views]
 
RSS Facebook Twitter LinkedDin
 
Top Sections
 
Top Stories